Suchergebnis: Katalogdaten im Herbstsemester 2017

MAS in Medizinphysik Information
Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen
Vertiefung Radiation Therapy
Kernfächer
NummerTitelTypECTSUmfangDozierende
402-0341-00LMedical Physics IW6 KP2V + 1UP. Manser
KurzbeschreibungIntroduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations.
LernzielUnderstanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society.
InhaltThe lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications.
SkriptA script will be provided.
227-0943-00LRadiobiologyW2 KP2VM. Pruschy
KurzbeschreibungThe purpose of this course is to impart basic knowledge in radiobiology in order to handle ionizing radiation and to provide a basis for predicting the radiation risk.
LernzielBy the end of this course the participants will be able to:
a) interpret the 5 Rs of radiation oncology in the context of the hallmarks of cancer
b) understand factors which underpin the differing radiosensitivities of different tumors
c) follow rational strategies for combined treatment modalities of ionizing radiation with targeted agents
d) understand differences in the radiation response of normal tissue versus tumor tissue
e) understand different treatment responses of the tumor and the normal tissue to differential clinical-related parameters of radiotherapy (dose rate, LET etc.).
InhaltEinführung in die Strahlenbiologie ionisierender Strahlen: Allgemeine Grundlagen und Begriffsbestimmungen; Mechanismen der biologischen Strahlenwirkung; Strahlenwirkung auf Zellen, Gewebe und Organe; Modifikation der biologischen Strahlenwirkung; Strahlenzytogenetik: Chromosomenveränderungen, DNA-Defekte, Reparaturprozesse; Molekulare Strahlenbiologie: Bedeutung inter- und intrazellulärer Signalübermittlungsprozesse, Apoptose, Zellzyklus-Checkpoints; Strahlenrisiko: Strahlensyndrome, Krebsinduktion, Mutationsauslösung, pränatale Strahlenwirkung; Strahlenbiologische Grundlagen des Strahlenschutzes; Nutzen-Risiko-Abwägungen bei der medizinischen Strahlenanwendung; Prädiktive strahlenbiologische Methoden zur Optimierung der therapeutischen Strahlenanwendung.
SkriptBeilagen mit zusammenfassenden Texten, Tabellen, Bild- und Grafikdarstellungen werden abgegeben
LiteraturLiteraturliste wird abgegeben.
Für NDS-Absolventen empfohlen: Hall EJ; Giacchia A: Radiobiology for the Radiologist, 7th Edition, 2011
Voraussetzungen / BesonderesThe former number of this course unit is 465-0951-00L.
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