Search result: Catalogue data in Autumn Semester 2016
MAS in Medical Physics | ||||||
Specialization: General Medical Physics and Biomedical Engineering | ||||||
Major in Molecular Biology and Biophysics | ||||||
Core Courses | ||||||
Number | Title | Type | ECTS | Hours | Lecturers | |
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227-0945-00L | Cell and Molecular Biology for Engineers I This course is part I of a two-semester course. | W | 3 credits | 3G | C. Frei | |
Abstract | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Objective | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Content | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed (part I: 1 Journal club, part II: 2 Journal Clubs). For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded and count as 25% for the final grade. | |||||
Lecture notes | Scripts of all lectures will be available. | |||||
Literature | "Molecular Biology of the Cell" (6th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 credits | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Abstract | Storage, handling and analysis of large datasets have become essential in biological research. The course will introduce students to a number of applications of bioinformatics in biology. Freely accessible software tools and databases will be explained and explored in theory and praxis. | |||||
Objective | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Content | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
551-1601-00L | Biophysics of Biological Macromolecules Does not take place this semester. The course will only take place with a minimum of 4 participants. | W | 6 credits | 2V + 1U | G. Wider, F. Allain | |
Abstract | This lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students. | |||||
Objective | Basics of molecular biology and biophysics in in view of the special interest of students in physics. | |||||
Content | This lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students. The topics include: properties of biological macromolecules, introduction to the genetic system of E.coli bacteria, transcription, translation, discussion of structure and function of proteins, quantitative description of enzyme function and allosteric interactions, biotechnology, introduction to optical spectroscopy, X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy of biopolymers in solution. | |||||
Lecture notes | - additional documentation in support of text book | |||||
Prerequisites / Notice | small classes with active participation of students |
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