535-0231-00L Medicinal Chemistry II

Abstract	The lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
Objective	Basic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
Content	Molecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions.
Lecture notes	Will be provided electronically in parts before each individual lecture.
Literature	- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press (2013) - D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005) - J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002) - A. Gringauz, "How Drugs Act and Why", Wiley (1997) - R. Silverman and M. Holladay, "The Organic Chemistry of Drug Design and Drug Action" 3rd Edition, Academic Press, (2014)
Prerequisites / Notice	Requirements: Knowledge of physical and organic chemistry, biochemistry and biology; Medicinal Chemistry I.