Paolo Arosio: Catalogue data in Autumn Semester 2022
|Name||Prof. Dr. Paolo Arosio|
Professur Biochem. Engineering
ETH Zürich, HCI F 129
|Telephone||+41 44 633 94 40|
|Department||Chemistry and Applied Biosciences|
|Relationship||Assistant Professor (Tenure Track)|
|529-0615-01L||Biochemical and Polymer Reaction Engineering||6 credits||3G||P. Arosio|
|Abstract||Polymerization reactions and processes. Homogeneous and heterogeneous (emulsion) kinetics of free radical polymerization. Post treatment of polymer colloids. Bioprocesses for the production of molecules and therapeutic proteins. Kinetics and design of aggregation processes of macromolecules and proteins.|
|Objective||The aim of the course is to learn how to design polymerization reactors and bioreactors to produce polymers and proteins with the specific product qualities that are required by different applications in chemical, pharmaceutical and food industry. This activity includes the post-treatment of polymer latexes, the downstream processing of proteins and the analysis of their colloidal behavior.|
|Content||We will cover the fundamental processes and the operation units involved in the production of polymeric materials and proteins. In particular, the following topics are discussed: Overview on the different polymerization processes. Kinetics of free-radical polymerization and use of population balance models. Production of polymers with controlled characteristics in terms of molecular weight distribution. Kinetics and control of emulsion polymerization. Surfactants and colloidal stability. Aggregation kinetics and aggregate structure in conditions of diffusion and reaction limited aggregation. Modeling and design of colloid aggregation processes. Physico-chemical characterization of proteins and description of enzymatic reactions. Operation units in bioprocessing: upstream, reactor design and downstream. Industrial production of therapeutic proteins. Characterization and engineering of protein aggregation. Protein aggregation in biology and in biotechnology as functional materials.|
|Lecture notes||Scripts are available on the web page of the Arosio-group: http://www.arosiogroup.ethz.ch/education.html|
Additional handout of slides will be provided during the lectures.
|Literature||R.J. Hunter, Foundations of Colloid Science, Oxford University Press, 2nd edition, 2001|
D. Ramkrishna, Population Balances, Academic Press, 2000
H.W. Blanch, D. S. Clark, Biochemical Engineering, CRC Press, 1995
|529-0632-00L||Homogeneous Reaction Engineering||4 credits||3G||P. Arosio|
|Abstract||Kinetics of homogeneous reactions. Ideal reactors: optimization of conversion and selectivity for complex kinetic networks. Thermal effects in chemical reactors. Residence time distribution. Analysis and design of real reactors. Fast reactions in turbulent flows. Sensitivity and stability of chemical reactors.|
|Objective||Provide to the students a complete methodology for the analysis and design of homogeneous reactors|
|Content||Kinetic models for homogeneous reactions. Collection and analysis of experimental rate data. Isothermal ideal reactors. Complex reaction networks. Reactor design for conversion and selectivity optimization. Adiabatic and non-isothermal reactors. Temperature effect on reversible reactions. Residence time distribution in chemical reactors. Role of mixing in turbolent reacting systems. Design of real reactors. Parametric sensitivity and stability in chemical reactors.|
|Lecture notes||Scripts are available on line on the web page of the Arosio group.|
|Literature||H.S. Fogler, Elements of Chemical Reaction Engineering, Prentice Hall, 3rd edition, 1999|
O. Levenspiel, Chemical Reaction Engineering, John Wiley, 3rd edition, 1999
|529-0690-00L||ICB Seminars on Chemical and Biochemical Engineering||1 credit||P. Arosio|
|Abstract||The ICB seminar series covers the umbrella of diverse research activities encompassed within the institute, including catalysis, functional materials, polymer engineering, separations, microfluidics, process design, and systems engineering. This series was founded with the aim or promoting cross-disciplinary scientific discourse and interaction with other distinguished groups working worldwide.|
|Objective||Students are expected to attend all seminars in one academic year, and should register at the beginning of each seminar. Additionally they must deliver a two page written report at the end of the year describing the topics covered, main conclusions, and interrelationships between the different themes.|
|Content||The ICB seminar series covers the umbrella of diverse research activities encompassed within the institute, including catalysis, functional materials, polymer engineering, separations, microfluidics, process design, and systems engineering. This series was founded with the aim or promoting cross-disciplinary scientific discourse and interaction with other distinguished groups working worldwide, and is targeted at individuals who have made outstanding contributions within their fields. Each year, around 7 distinguished scientists and technologists will be invited to speak on topics of current interest in Chemical and Biochemical Engineering. PhD students are particularly encouraged to attend in order to broaden their perception and enrich their scientific horizons.|
|551-0357-00L||Cellular Matters: From Milestones to Open Questions|
The number of participants is limited to 22 and will only take place with a minimum of 11 participants.
Please sign up until two weeks before the beginning of the semester (for Autumn 2022: by 05.09.2022 end of day) via e-mail to firstname.lastname@example.org using in the subject: 551-0357-00. In the email body indicate 1) your name, 2) your e-mail address, 3) master/PhD program. The students admitted to this seminar will be informed by e-mail in the week prior to the beginning of the semester.
The first lecture will serve to form groups of students and assign papers.
|4 credits||2S||Y. Barral, F. Allain, P. Arosio, E. Dufresne, D. Hilvert, M. Jagannathan, R. Mezzenga, T. Michaels, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers|
|Abstract||In this course, the students will explore the quite new topic of biomolecular condensates.|
Concepts and tools from biology, chemistry, biophysics and soft materials will be used, on one hand, to develop an understanding of the biological properties and functions of biomolecular condensates in health and disease, while, on the other, to inspire new materials.
|Objective||In terms of content, you, the student, after a general introduction to the topic, will learn about milestone works and current research questions in the young field of biomolecular condensates (properties, functions and applications) from an interdisciplinary point of view in a course which is a combination of literature (presentations given by pairs of students with different scientific backgrounds) and research seminars (presentations given by the lecturers all active experts in the field, with different backgrounds and expertise).|
As to the skills, you will have the opportunity to learn how to critically read and evaluate scientific literature, how to give scientific presentations to an interdisciplinary audience (each presentation consisting of an introduction, critical description of the results and discussion of their significance) and substantiate your statements, acquire a critical mindset (pros/cons of chosen approaches/methods and limitations, quality of the data, solidity of the conclusions, possible follow-up experiments) that allows you to ask relevant questions and actively participate to the discussion.
With the final presentation you will have the unique opportunity to interact closely with the interdisciplinary group of lecturers (all internationally well-established experts) who will guide you in the choice of a subtopic and related literature.
|Content||In the last decade a new kind of compartments within the cell, the so-called biomolecular condensates, have been observed. This discovery is radically changing our understanding of the cell, its organization and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less sub-compartments, similarly to emulsions.|
The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and needs a multi-pronged approach that levers on, and cross-fertilizes, biology, physical chemistry, biophysics and soft materials to develop a proper understanding of the properties, functions in health and disease (Alzheimer’s, Parkinson’s, etc.), as well as possible applications of these biomolecular condensates.
Each week the lecture will consist of:
1) a short literature seminar: Pairs of students from different scientific backgrounds will be formed and assigned beforehand to present milestone literature to the class and facilitate the ensuing discussion. In the first class the pairs will be formed, the milestone papers made known to the whole class and assigned to the pairs.
2) a research seminar: the presentation of the milestone literature will serve as the introduction to the lecture by one of the lecturers of the course on their own state-of-the-art research in the field.
|Lecture notes||The presentations will be made available after the lectures.|
|Literature||The milestone papers will be provided in advance.|
For the final examination, the students will be helped by the lecturers in identifying a research topic and related literature.