|Name||Prof. Dr. Wolf-Dietrich Hardt|
Institut für Mikrobiologie
ETH Zürich, HCI G 417
|Telephone||+41 44 632 51 43|
|Fax||+41 44 632 11 29|
|551-0110-00L||Fundamentals of Biology II: Microbiology||2 credits||2V||J. Vorholt-Zambelli, W.‑D. Hardt, J. Piel|
|Abstract||Bacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions|
|Objective||Basic principles of cell structure, growth physiology, energy metabolism, gene expression and regulation. Biodiversity of Bacteria and Archaea. Phylogeny and evolution.|
|Content||Bacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions|
|Literature||Brock, Biology of Microorganisms (Madigan, M.T. and Martinko, J.M., eds.), 14th ed., Pearson Prentice Hall, 2015|
|551-0126-00L||Fundamentals of Biology II: Cells||6 credits||5G||K. Weis, F. Allain, Y. Barral, W.‑D. Hardt, U. Kutay, M. Peter, I. Zemp|
|Abstract||The lecture provides an introduction to the function and regulations of cells.|
|Objective||Introduction to the function and regulation of cells|
|Content||The lecture introduces a basic understanding of the structure, organization, function and regulation of the cell. The lecture is divided into two main sections:|
Part 1: Cell Biology of Prokaryotes, evolution, populations
This section covers the general principles of the structure and regulation of prokaryotic cells, and explains the genetics and the evolution of bacteria.
Part II: Unifying concepts in Eukarya
This part of the lecture gives a broad introduction into the general structure of eukaryotic cells and illustrates key concepts such as intracellular architecture, transport mechanisms and the regulation of gene expression in eukaryotes.
|Lecture notes||The newly conceived lecture is supported by scripts.|
|Literature||The lecture is supported by scripts. Furthermore, the textbook "Molecular Biology of the Cell", Alberts et al. 6th edition, Taylor and Francis, and "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson can be used as support for the lecture.|
|551-0314-00L||Microbiology (Part II)||3 credits||2V||W.‑D. Hardt, L. Eberl, J. Piel, J. Vorholt-Zambelli|
|Abstract||Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Objective||This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Content||Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Lecture notes||Updated handouts will be provided during the class.|
|Literature||Current literature references will be provided during the lectures.|
|Prerequisites / Notice||English|
|551-0509-00L||Current Immunological Research in Zurich||0 credits||1K||R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers|
|Abstract||This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion.|
|Objective||The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups.|
|Content||Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich.|
|551-1100-00L||Infectious Agents: From Molecular Biology to Disease|
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
|4 credits||2S||W.‑D. Hardt, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander, further lecturers|
|Abstract||Literature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.|
|Objective||Working with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.|
|Content||for each model pathogen (or key technology):|
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
|Lecture notes||Teachers will provide the research papers to be discussed.|
Students will prepare handouts for the rest of the group for their assigned seminar.
|Literature||Teachers will provide the research papers to be discussed.|
|Prerequisites / Notice||Restricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to firstname.lastname@example.org and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.|
The first seminar date will serve to form groups of students and assign a paper to each group.
|551-1106-00L||Progress Reports in Microbiology and Immunology|
Students must sign up via secr.micro.biol.ethz.ch
|0 credits||5S||J. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli|
|Abstract||Presentation and discussion of current research results in the field of Microbiology and Infection Immunology|
|Objective||Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims|
|551-1109-00L||Seminars in Microbiology||0 credits||2K||W.‑D. Hardt, M. Künzler, J. Piel, S. Sunagawa, J. Vorholt-Zambelli|
|Abstract||Seminars by invited speakers covering selected microbiology themes.|
|Objective||Discussion of selected microbiology themes presented by invited speakers.|
|551-1110-00L||Infection and Immunology |
Only for Health Sciences and Technology BSc and Human Medicine BSc.
|2 credits||2V||W.‑D. Hardt, A. B. Hehl, U. Karrer, F. Sallusto|
|Abstract||Structure and function of pathogenic bacteria, viruses, single- and multi-cellular parasites, and pathogen-specific defense mechanisms of the immune system. The lecture is complemented by a learning platform. Some material is expected to be prepared in self-study|
|Objective||- Students can describe the structural principles and mechanisms of infection of key pathogens.|
- Students understand how these pathogens are detected and eliminated by the native and adaptive immune system.
- Students are able to explain how anti-infective agents work and how pathogens develop resistance.
|Content||- Cellular structure of Gram-positive and Gram-negative bacteria|
- Bacteria-host interactions and their effect on the host
- Antibiotics and antibiotic resistance
- Classification of pathogenic viruses
- Organization, classification and life cycle of eukaryotic pathogens
- Organization of the native immune system
- Organization of the adaptive immune system
|Prerequisites / Notice||The immunology section of the course can be taught in English.|
|551-1126-00L||Technologies in Molecular Microbiology||4 credits||2V||B. Nguyen, W.‑D. Hardt, further lecturers|
|Abstract||The lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.|
|Objective||The lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, cellular, and community analysis . Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.|
|Content||Important genetic, biochemical, biophysical, and community analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.|
List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
|Lecture notes||Updated handouts will be provided during the class.|
|Literature||Current literature references, relevant papers and handouts will be provided during the lectures.|
|Prerequisites / Notice||The following lecturers will contribute to the course:|
Dr. Alex Brachmann (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Florian Freimoser (Agroscope)
Dr. Jonas Grossmann (FGCZ)
Annika Hausmann (ETH)
Dr. Bidong Nguyen (ETH)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)