Yves Barral: Catalogue data in Spring Semester 2019
|Name||Prof. Dr. Yves Barral|
Institut für Biochemie
ETH Zürich, HPM D 8.3
|Telephone||+41 44 632 06 78|
|Fax||+41 44 632 15 91|
|551-0103-AAL||Fundamentals of Biology II: Cell Biology|
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.
Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
|5 credits||11R||U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner|
|Abstract||The goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Objective||The goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.|
|Content||The focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.|
|Literature||Alberts et al. 'Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244 (paperback).|
Analyzing cells & molecules / Gebhard Schertler/8/ 439-463;
Membrane structure / Gebhard Schertler/ 10/ 565-595;
Compartments and Sorting/ Ulrike Kutay/12+14+6/641-694/755-758/782-783/315-320/325 -333/Table 6-2/Figure6-20, 6-21, 6-32, 6-34;
Intracellular Membrane Traffic/ Ulrike Kutay/13/695-752;
The Cytoskeleton/ Ulrike Kutay/ 16/889 - 948 (only the essentials);
Membrane Transport of Small Molecules and the Electrical Properties of Membranes /Sabine Werner/11/597 - 633;
Mechanisms of Cell Communication / Sabine Werner/15/813-876;
Cancer/ Sabine Werner/20/1091-1141;
Cell Junctions and Extracellular Matrix/Ueli Suter / 1035-1081;
Stem Cells and Tissue Renewal/Ueli Suter /1217-1262;
Development of Multicellular organisms/ Ernst Hafen/ 21/ 1145-1179 /1184-1198/1198-1213;
Cell Migration/Joao Matos/951-960;
Cell Death/Joao Matos/1021-1032;
Cell Cycle/chromosome segregation/Cell division/Meiosis/Joao Matos/ 963-1018.
|Prerequisites / Notice||none|
|551-0320-00L||Cellular Biochemistry (Part II)||3 credits||2V||Y. Barral, R. Kroschewski, A. E. Smith|
|Abstract||This course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.|
|Objective||The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. |
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
|Content||Spatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.|
|Literature||Recommended supplementary literature (review articles and selected primary literature) will be provided during the course.|
|Prerequisites / Notice||To attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.|
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
|551-0339-00L||Molecular Mechanisms of Cell Dynamics |
Number of participants limited to 13.
The enrolment is done by the D-BIOL study administration.
|6 credits||7G||E. Dultz, Y. Barral, U. Kutay, M. Peter, K. Weis|
|Abstract||Application of current strategies to study complex and highly regulated cellular processes during cell division and growth.|
|Objective||The students learn to evaluate and to apply the current strategies to study complex and highly regulated cellular processes during cell division and growth.|
|Content||During this Block-Course, the students will learn to (1) describe the main regulators and the mechanics of cell division and growth, (2) perform standard lab techniques and quantitate dynamic cellular processes during cell division and growth, (3) evaluate and compare experimental strategies and model systems, (4) independently search and critically evaluate scientific literature on a specific problem and present it in a seminar, and (5) formulate scientific concepts (preparation and presentation of a poster).|
Students will work in small groups in individual labs on one research project (8 full days of practical work; every group of students will stay in the same lab during the entire course). The projects are close to the actual research carried out in the participating research groups, but with a clear connection to the subject of the course.
|Literature||Documentation and recommended literature (review articles and selected primary literature) will be provided during the course.|
|Prerequisites / Notice||This course will be taught in english.|
|551-1300-00L||Cause and Consequences of Unstable Genomes |
Number of participants limited to 15.
The enrolment is done by the D-BIOL study administration.
|6 credits||7G||J. Fernandes de Matos, Y. Barral, C. Beyer, P. Cejka, R. Kroschewski, G. Schwank|
|Abstract||The course will introduce students to key concepts and laboratory research within the broad field of "Genome stability".|
|Objective||Students will learn to design, apply and evaluate current research strategies in a wide range of modern research areas encompassing the broad field of "Genome stability".|
|Content||The course will consist of lectures, practical laboratory work in small groups, informal progress report sessions, and preparation and presentation of a poster. Lectures will be presented mainly at the start of the course to expose students to key concepts and techniques in the field. Students will team into small groups and work in one laboratory for the rest of the course. Students will meet regularly for informal "progress report" discussions of their projects. Student performance will be assessed based on the quality of their practical work, a written exam on frontal lecture material, and a poster presentation of their practical work.|
|Literature||Documentation and recommended literature in the form of review articles and selected primary literature will be provided during the course.|
|Prerequisites / Notice||This course will be taught in English.|